RAS Drug Discovery is popular PDF and ePub book, written by Adrian Gill in 2024-11-01, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, RAS Drug Discovery can be Read Online from any device for your convenience.
RAS Drug Discovery Book PDF Summary
KRAS Drug Discovery: Past, Present and Future is a comprehensive overview of the state-of-the-art medicinal chemistry approaches towards targeting the formerly undruggable oncogene, KRAS. It includes Seminal medicinal chemistry case histories of KRASG12C inhibitors such as Sotorosib, the first approved KRASG12C inhibitor for NSCLC, alongside the latest advances towards identification of in vivo tools and development candidates targeting KRAS G12D, KRAS G13C and other mutations. The book also provides the reader with a comprehensive overview of the in vitro assay systems, in vivo pharmacology xenograft models and chemical biology tools available to characterize small molecule inhibitors of KRAS. Highlights key structure-based drug design (SBDD) innovations to generate potency and selectivity vs. KRAS Analyzes medicinal chemistry case histories for seminal contributions to the KRAS field Provides an overview of in vitro and in vivo methods for drugging KRAS
Detail Book of RAS Drug Discovery PDF
- Author : Adrian Gill
- Release : 01 November 2024
- Publisher : Elsevier
- ISBN : 9780443218620
- Genre : Science
- Total Page : 0 pages
- Language : English
- PDF File Size : 18,5 Mb
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