The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis is popular PDF and ePub book, written by Domenico Ribatti in 2010-01-28, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis can be Read Online from any device for your convenience.
The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis Book PDF Summary
The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which serves as a gas exchange surface and its function is supported by a dense capillary network. Because of its extensive vascularization and easy accessibility, the CAM has been broadly used to study the morpho-functional aspects of the angiogenesis process in vivo and to investigate the efficacy and mechanisms of action of pro-angiogenic and anti-angiogenic natural and synthetic molecules. The CAM is a suitable site for transplanting tissues, which can survive and develop in the CAM by peripheral anastomoses between graft and original CAM vasculature or by new angiogenic vessels grown from the CAM that invade the graft. While the formation of peripheral anastomoses between host and pre-existing donor vessels is the main, and the most common, mechanism involved in the revascularization of embryonic grafts, the growth of CAM-derived vessels into the graft is only stimulated in tumor grafts. The CAM has long been a favored system for the study of tumor angiogenesis and metastasis, because at this stage the chick immunocompetence system is not fully developed and the conditions for rejection have not been established. Tumors remain avascular for 72 h, after which they are penetrated by new blood vessels and begin a phase of rapid growth. Also, delivery of tumor cells onto the CAM allows the fine study of the effects of tumor derived angiogenic growth factors on blood vessel structure and functionality. The CAM may also used to verify the ability to inhibit the growth of capillaries by implanting tumors onto the CAM and by comparing tumor growth and vascularization with or without the administration of an anti-angiogenic molecule. Other studies using the tumor cells/CAM model have focused on the invasion of the chorionic epithelium and the blood vessels by tumor cells. The cells invade the epithelium and the mesenchymal connective tissue below, where they are found in the form of a dense bed of blood vessels, which is a target for intravasation.
Detail Book of The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis PDF
- Author : Domenico Ribatti
- Release : 28 January 2010
- Publisher : Springer Science & Business Media
- ISBN : 9789048138456
- Genre : Medical
- Total Page : 130 pages
- Language : English
- PDF File Size : 20,8 Mb
If you're still pondering over how to secure a PDF or EPUB version of the book The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis by Domenico Ribatti, don't worry! All you have to do is click the 'Get Book' buttons below to kick off your Download or Read Online journey. Just a friendly reminder: we don't upload or host the files ourselves.