Scaffold Hopping in Medicinal Chemistry is popular PDF and ePub book, written by Nathan Brown in 2013-11-06, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Scaffold Hopping in Medicinal Chemistry can be Read Online from any device for your convenience.
Scaffold Hopping in Medicinal Chemistry Book PDF Summary
This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.
Detail Book of Scaffold Hopping in Medicinal Chemistry PDF
- Author : Nathan Brown
- Release : 06 November 2013
- Publisher : John Wiley & Sons
- ISBN : 9783527665167
- Genre : Medical
- Total Page : 440 pages
- Language : English
- PDF File Size : 16,6 Mb
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