Bioisosteres in Medicinal Chemistry is popular PDF and ePub book, written by Nathan Brown in 2012-06-18, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Bioisosteres in Medicinal Chemistry can be Read Online from any device for your convenience.
Bioisosteres in Medicinal Chemistry Book PDF Summary
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
Detail Book of Bioisosteres in Medicinal Chemistry PDF
- Author : Nathan Brown
- Release : 18 June 2012
- Publisher : John Wiley & Sons
- ISBN : 9783527654321
- Genre : Medical
- Total Page : 249 pages
- Language : English
- PDF File Size : 13,6 Mb
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