Peptidomimetics in Organic and Medicinal Chemistry is popular PDF and ePub book, written by Antonio Guarna in 2014-03-14, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, Peptidomimetics in Organic and Medicinal Chemistry can be Read Online from any device for your convenience.
Peptidomimetics in Organic and Medicinal Chemistry Book PDF Summary
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Detail Book of Peptidomimetics in Organic and Medicinal Chemistry PDF
- Author : Antonio Guarna
- Release : 14 March 2014
- Publisher : John Wiley & Sons
- ISBN : 9781118683149
- Genre : Science
- Total Page : 334 pages
- Language : English
- PDF File Size : 14,5 Mb
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