Advances in Medicinal Chemistry is popular PDF and ePub book, written by B.E. Maryanoff in 1999-04-01, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, Advances in Medicinal Chemistry can be Read Online from any device for your convenience.
Advances in Medicinal Chemistry Book PDF Summary
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
Detail Book of Advances in Medicinal Chemistry PDF
- Author : B.E. Maryanoff
- Release : 01 April 1999
- Publisher : Elsevier
- ISBN : 0080526373
- Genre : Science
- Total Page : 321 pages
- Language : English
- PDF File Size : 8,8 Mb
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