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Optimized Response Adaptive Clinical Trials Book PDF Summary

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences. Contents Introduction to Markov Decision Problems and Examples Finite and Infinite Horizon Markov Decision Problems Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration Designing Response Adaptive Clinical Trials with Markov Decision Problems Target Groups Researchers and students in the fields of mathematics and statistics Professionals in the pharmaceutical industry

Detail Book of Optimized Response Adaptive Clinical Trials PDF

Optimized Response Adaptive Clinical Trials
  • Author : Thomas Ondra
  • Release : 30 September 2024
  • Publisher : Unknown
  • ISBN : 365808345X
  • Genre : Uncategoriezed
  • Total Page : null pages
  • Language : English
  • PDF File Size : 15,7 Mb

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