Randomised Response Adaptive Designs in Clinical Trials is popular PDF and ePub book, written by Anthony C Atkinson in 2013-12-26, it is a fantastic choice for those who relish reading online the Mathematics genre. Let's immerse ourselves in this engaging Mathematics book by exploring the summary and details provided below. Remember, Randomised Response Adaptive Designs in Clinical Trials can be Read Online from any device for your convenience.
Randomised Response Adaptive Designs in Clinical Trials Book PDF Summary
Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.
Detail Book of Randomised Response Adaptive Designs in Clinical Trials PDF
- Author : Anthony C Atkinson
- Release : 26 December 2013
- Publisher : CRC Press
- ISBN : 9781584886938
- Genre : Mathematics
- Total Page : 341 pages
- Language : English
- PDF File Size : 15,5 Mb
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