Endoplasmic Reticulum Stress in Health and Disease is popular PDF and ePub book, written by Patrizia Agostinis in 2012-08-13, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Endoplasmic Reticulum Stress in Health and Disease can be Read Online from any device for your convenience.
Endoplasmic Reticulum Stress in Health and Disease Book PDF Summary
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
Detail Book of Endoplasmic Reticulum Stress in Health and Disease PDF
- Author : Patrizia Agostinis
- Release : 13 August 2012
- Publisher : Springer Science & Business Media
- ISBN : 9789400743519
- Genre : Medical
- Total Page : 448 pages
- Language : English
- PDF File Size : 15,8 Mb
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