B Cell Receptor Signaling is popular PDF and ePub book, written by Tomohiro Kurosaki in 2015-12-26, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, B Cell Receptor Signaling can be Read Online from any device for your convenience.
B Cell Receptor Signaling Book PDF Summary
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Detail Book of B Cell Receptor Signaling PDF
- Author : Tomohiro Kurosaki
- Release : 26 December 2015
- Publisher : Springer
- ISBN : 9783319261331
- Genre : Medical
- Total Page : 231 pages
- Language : English
- PDF File Size : 8,8 Mb
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