Tumor Suppressor Par 4 is popular PDF and ePub book, written by Vivek M. Rangnekar in 2022-01-01, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Tumor Suppressor Par 4 can be Read Online from any device for your convenience.
Tumor Suppressor Par 4 Book PDF Summary
Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.
Detail Book of Tumor Suppressor Par 4 PDF
- Author : Vivek M. Rangnekar
- Release : 01 January 2022
- Publisher : Springer Nature
- ISBN : 9783030805586
- Genre : Medical
- Total Page : 329 pages
- Language : English
- PDF File Size : 14,6 Mb
If you're still pondering over how to secure a PDF or EPUB version of the book Tumor Suppressor Par 4 by Vivek M. Rangnekar, don't worry! All you have to do is click the 'Get Book' buttons below to kick off your Download or Read Online journey. Just a friendly reminder: we don't upload or host the files ourselves.