The Neuroendocrine Leydig Cells and their Stem Cell Progenitors the Pericytes is popular PDF and ePub book, written by Michail S. Davidoff in 2009-07-15, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, The Neuroendocrine Leydig Cells and their Stem Cell Progenitors the Pericytes can be Read Online from any device for your convenience.
The Neuroendocrine Leydig Cells and their Stem Cell Progenitors the Pericytes Book PDF Summary
cells, and the testicular localization of the intermediate filament protein nestin, known to be expressed in neural stem cells, by our group was the first step to define mural cells (pericytes and vascular smooth muscle cells) of the testis microvascu- ture as the stem/progenitor cells of the adult Leydig cells. In summary, we were able to demonstrate specific proliferation of vascular progenitors and their subsequent transdifferentiation into steroidogenic Leydig cells, which – in addition – rapidly acquire neuronal and glial properties. Since both newly developed fetal and adult Leydig cell populations show the same features, a common origin of both popu- tions seems likely. Pericytes are distributed throughout the body, and there is convincing evidence for their stem/progenitor cell properties in diverse organs. Under appropriate (locally defined) conditions these pericytes, which reside in the vascular stem cell niche as dormant stem cells, become activated, proliferate, migrate and differentiate towards different somatic cell types of the body. Since most mesenchymal stem/ progenitor cell types exhibit essential similarity to pericytes and certain mesenchymal stem cells represent pericyte descendants, we propose that mesenchymal stem cells in the perivascular niche are daughter cells of pericytes. Thus, pericytes are promising candidates for ancestor cells of all adult stem cells in the organism. There is strong evidence that early stem cells (cells arising during embryogenesis), such as the pericytes, exhibit both mesodermal and neural progeny, which might explain the neuroendocrine properties of the Leydig cells.
Detail Book of The Neuroendocrine Leydig Cells and their Stem Cell Progenitors the Pericytes PDF
- Author : Michail S. Davidoff
- Release : 15 July 2009
- Publisher : Springer Science & Business Media
- ISBN : 9783642005138
- Genre : Medical
- Total Page : 157 pages
- Language : English
- PDF File Size : 8,7 Mb
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