The ADAM Family of Proteases is popular PDF and ePub book, written by Nigel M Hooper in 2006-07-02, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, The ADAM Family of Proteases can be Read Online from any device for your convenience.
The ADAM Family of Proteases Book PDF Summary
The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.
Detail Book of The ADAM Family of Proteases PDF
- Author : Nigel M Hooper
- Release : 02 July 2006
- Publisher : Springer Science & Business Media
- ISBN : 9780387251516
- Genre : Science
- Total Page : 351 pages
- Language : English
- PDF File Size : 13,5 Mb
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