Synthesis and Biological Evaluation of Pyrrole Imidazole Polyamide Probes for Visualization of Telomeres is popular PDF and ePub book, written by Yusuke Kawamoto in 2019-03-07, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, Synthesis and Biological Evaluation of Pyrrole Imidazole Polyamide Probes for Visualization of Telomeres can be Read Online from any device for your convenience.
Synthesis and Biological Evaluation of Pyrrole Imidazole Polyamide Probes for Visualization of Telomeres Book PDF Summary
This book presents a novel method of synthesizing sequence-specific DNA binding pyrrole–imidazole (Py–Im) polyamides and demonstrates polyamides targeting longer base pairs than those previously reported and their cellular application. It discusses the development of the facile synthetic method of tandem hairpin Py–Im polyamides and the method of visualizing telomeres under mild conditions without harsh denaturation, as well as research resulting in the synthesis not only of previously reported tandem dimer polyamides but also longer tandem trimer and tetramer polyamides. Using fluorescently labeled tandem hairpin Py–Im polyamides targeting a human telomere repetitive sequence, the author successfully stained telomeres in fixed cells without denaturation. These fluorescently labeled tandem tetramer polyamides are able to visualize human telomeres with lower background signals than previous polyamide probes, suggesting that they have higher specificity for telomeres. As such, this book provides insights into recent advance in Py–Im polyamides, particularly the extension of the target sites c
Detail Book of Synthesis and Biological Evaluation of Pyrrole Imidazole Polyamide Probes for Visualization of Telomeres PDF
- Author : Yusuke Kawamoto
- Release : 07 March 2019
- Publisher : Springer
- ISBN : 9789811369124
- Genre : Science
- Total Page : 122 pages
- Language : English
- PDF File Size : 13,5 Mb
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