Sperm Acrosome Biogenesis and Function During Fertilization is popular PDF and ePub book, written by Mariano G. Buffone in 2016-05-19, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Sperm Acrosome Biogenesis and Function During Fertilization can be Read Online from any device for your convenience.
Sperm Acrosome Biogenesis and Function During Fertilization Book PDF Summary
Over the last decades, acrosomal exocytosis (also called the “acrosome reaction”) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.
Detail Book of Sperm Acrosome Biogenesis and Function During Fertilization PDF
- Author : Mariano G. Buffone
- Release : 19 May 2016
- Publisher : Springer
- ISBN : 9783319305677
- Genre : Medical
- Total Page : 176 pages
- Language : English
- PDF File Size : 11,7 Mb
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