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Purine Metabolism in Man Book PDF Summary

Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari fication.

Detail Book of Purine Metabolism in Man PDF

Purine Metabolism in Man
  • Author : Oded Sperling
  • Release : 11 November 2013
  • Publisher : Springer Science & Business Media
  • ISBN : 9781475714333
  • Genre : Science
  • Total Page : 453 pages
  • Language : English
  • PDF File Size : 10,9 Mb

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Purine Metabolism in Man II

Purine Metabolism in Man   II Author : Mathias M. Muller
Publisher : Springer Science & Business Media
File Size : 26,9 Mb
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The study of gouty arthritis has provided a common meeting ground for the research interests of both...

Purine Metabolism in Man II

Purine Metabolism in Man   II Author : Mathias M. Muller
Publisher : Springer Science & Business Media
File Size : 21,9 Mb
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The study of gouty arthritis has provided a common meeting ground for the research interests of both...

Purine Metabolism in Man IV

Purine Metabolism in Man IV Author : Chris H. De Bruyn
Publisher : Springer Science & Business Media
File Size : 33,7 Mb
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These two volumes, entitled "Purine Metabolism in Man IV" con tain the papers presented at the Fourt...

Purine Metabolism in Man

Purine Metabolism in Man Author : Oded Sperling
Publisher : Springer Science & Business Media
File Size : 15,6 Mb
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Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only r...

Purine Metabolism in Man III

Purine Metabolism in Man  III Author : A. Rapado
Publisher : Springer Science & Business Media
File Size : 43,7 Mb
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These volumes contain the papers which were presented at the Third International Symposium on Purine...

Purine and Pyrimidine Metabolism in Man VII

Purine and Pyrimidine Metabolism in Man VII Author : R. Angus Harkness,T.B. Elion,N. Zöllner
Publisher : Springer Science & Business Media
File Size : 40,7 Mb
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These two volumes record the scientific and clinical work presented at the VIIth International and 3...