Proteopathic Seeds and Neurodegenerative Diseases is popular PDF and ePub book, written by Mathias Jucker in 2013-03-27, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Proteopathic Seeds and Neurodegenerative Diseases can be Read Online from any device for your convenience.
Proteopathic Seeds and Neurodegenerative Diseases Book PDF Summary
The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer ́s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society.
Detail Book of Proteopathic Seeds and Neurodegenerative Diseases PDF
- Author : Mathias Jucker
- Release : 27 March 2013
- Publisher : Springer Science & Business Media
- ISBN : 9783642354915
- Genre : Medical
- Total Page : 163 pages
- Language : English
- PDF File Size : 8,8 Mb
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