Protein Tyrosine Kinases is popular PDF and ePub book, written by Doriano Fabbro in 2007-11-13, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, Protein Tyrosine Kinases can be Read Online from any device for your convenience.
Protein Tyrosine Kinases Book PDF Summary
Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.
Detail Book of Protein Tyrosine Kinases PDF
- Author : Doriano Fabbro
- Release : 13 November 2007
- Publisher : Springer Science & Business Media
- ISBN : 9781592599622
- Genre : Science
- Total Page : 599 pages
- Language : English
- PDF File Size : 8,9 Mb
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