Prediction and prevention of prescription drug abuse is popular PDF and ePub book, written by Julie A. Marusich in 2013-07-22, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Prediction and prevention of prescription drug abuse can be Read Online from any device for your convenience.
Prediction and prevention of prescription drug abuse Book PDF Summary
In 2011, the prevalence of prescription drug abuse exceeded that of any other illicit drug except marijuana. Consequently, efforts to curtail abuse of new medications should begin during the drug development process, where abuse liability can be identified and addressed before a candidate medication has widespread use. The first step in this process is scheduling with the Drug Enforcement Agency so that legal access is appropriately restricted, dependent upon levels of abuse risk and medical benefit. To facilitate scheduling, the Food and Drug Administration (FDA) has published guidance for industry that describes assessment of abuse liability. The purpose of this paper is to review methods that may be used to satisfy the FDA's regulatory requirements for animal behavioral and dependence pharmacology. Methods include psychomotor activity, self-administration (an animal model of the rewarding effects of a drug), drug discrimination (an animal model of the subjective effects of a drug), and evaluation of tolerance and dependence. Data from tests with known drugs of abuse illustrate typical results. While the use of preclinical data to predict abuse liability is an imperfect process, these methods have substantial predictive validity. The ultimate goal is to increase consumer safety through appropriate scheduling of new medications.
Detail Book of Prediction and prevention of prescription drug abuse PDF
- Author : Julie A. Marusich
- Release : 22 July 2013
- Publisher : RTI Press
- ISBN : 978186723xxxx
- Genre : Medical
- Total Page : 16 pages
- Language : English
- PDF File Size : 19,7 Mb
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