Polyglutamine Disorders is popular PDF and ePub book, written by Clévio Nóbrega in 2018-02-09, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Polyglutamine Disorders can be Read Online from any device for your convenience.
Polyglutamine Disorders Book PDF Summary
This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
Detail Book of Polyglutamine Disorders PDF
- Author : Clévio Nóbrega
- Release : 09 February 2018
- Publisher : Springer
- ISBN : 9783319717791
- Genre : Medical
- Total Page : 469 pages
- Language : English
- PDF File Size : 16,7 Mb
If you're still pondering over how to secure a PDF or EPUB version of the book Polyglutamine Disorders by Clévio Nóbrega, don't worry! All you have to do is click the 'Get Book' buttons below to kick off your Download or Read Online journey. Just a friendly reminder: we don't upload or host the files ourselves.