Permutation Testing for Isotonic Inference on Association Studies in Genetics is popular PDF and ePub book, written by Luigi Salmaso in 2011-07-16, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Permutation Testing for Isotonic Inference on Association Studies in Genetics can be Read Online from any device for your convenience.
Permutation Testing for Isotonic Inference on Association Studies in Genetics Book PDF Summary
The purpose of this book is to illustrate a new statistical approach to test allelic association and genotype-specific effects in the genetic study of diseases. There are some parametric and non-parametric methods available for this purpose. We deal with population-based association studies, but comparisons with other methods will also be drawn, analysing the advantages and disadvantages of each one, particularly with regard to power properties with small sample sizes. In this framework we will work out some nonparametric statistical permutation tests and likelihood-based tests to perform case-control analyses to study allelic association between marker, disease-gene and environmental factors. Permutation tests, in particular, will be extended to multivariate and more complex studies, where we deal with several genes and several alleles together. Furthermore, we show simulations under different assumptions on the genetic model and analyse real data sets by simply studying one locus with the permutation test.
Detail Book of Permutation Testing for Isotonic Inference on Association Studies in Genetics PDF
- Author : Luigi Salmaso
- Release : 16 July 2011
- Publisher : Springer
- ISBN : 3642205852
- Genre : Medical
- Total Page : 72 pages
- Language : English
- PDF File Size : 13,7 Mb
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