Peritoneal Carcinomatosis Drugs and Diseases is popular PDF and ePub book, written by Paul H. Sugarbaker in 2012-12-06, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Peritoneal Carcinomatosis Drugs and Diseases can be Read Online from any device for your convenience.
Peritoneal Carcinomatosis Drugs and Diseases Book PDF Summary
Peritoneal carcinomatosis dominates the clinical picture of many patients with gastrointestinal, gynecological and urological cancers. For many of them its dev astating effects contribute directly to their death. Most clinicians consider peritoneal carcinomatosis an incurable metastatic disease and give palliative treatment, re stricted to limited surgery and systemic chemotherapy. Contrary to this view, Paul Sugarbaker and his collegues base their approach on the concept that peritoneal carcinomatosis represents regional tumor spread, similar in its impact on treatment and prognosis to that of lymph node metastases in other malignancies. This concept emphasises the value of regional tumor control, as a potentially curative measure. In this book the combination of aggressive cytoreduction and intraperitoneal chemotherapy to control peritoneal carcinomatosis is extensively explored. Basic to this approach is the observation that most cancer cells show only relative resistence against commonly available drugs, which can be overcome by a sufficient increase of drug concentrations in tumor tissue. After intraperitoneal delivery, drugs will reach high tissue concentrations in the superficial few cell layers, while plasma concentrations will remain below toxic levels. Patients with only limited residual tumor at the peritoneal surface after cytoreduction may therefore benefit from intraperitoneal chemotherapy.
Detail Book of Peritoneal Carcinomatosis Drugs and Diseases PDF
- Author : Paul H. Sugarbaker
- Release : 06 December 2012
- Publisher : Springer Science & Business Media
- ISBN : 9781461312451
- Genre : Medical
- Total Page : 288 pages
- Language : English
- PDF File Size : 10,6 Mb
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