Membrane Transporters and Channels as Targets for Drugs is popular PDF and ePub book, written by Graça Soveral in 2020-01-03, it is a fantastic choice for those who relish reading online the Uncategoriezed genre. Let's immerse ourselves in this engaging Uncategoriezed book by exploring the summary and details provided below. Remember, Membrane Transporters and Channels as Targets for Drugs can be Read Online from any device for your convenience.
Membrane Transporters and Channels as Targets for Drugs Book PDF Summary
Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. There is increasing evidence that membrane transport proteins play important functions in healthy conditions and that their absence or dysfunction may cause diseases. In recent years much attention has been paid to diseases resulting from defective transporters (“carrier diseases”) and ion channels (“channelopathies”). Very interestingly, altered expression of transporters has been described in several human pathologies. On this basis, many transport proteins are well acknowledged targets for drugs. Many others are involved in drug delivery and disposition and/or are considered potential targets. Others are off-targets for drugs and then, are responsible for side effects. Thus, membrane protein drug discovery is now an emerging field where the search for physiological mechanisms of regulation and for chemical compounds as modulators of transport activity, present new opportunities for drug development and for new therapies. This Research Topic addresses the latest research advances in membrane transport proteins, stimulating future research on these important protein families.
Detail Book of Membrane Transporters and Channels as Targets for Drugs PDF
- Author : Graça Soveral
- Release : 03 January 2020
- Publisher : Frontiers Media SA
- ISBN : 9782889633579
- Genre : Uncategoriezed
- Total Page : 333 pages
- Language : English
- PDF File Size : 14,6 Mb
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