Mechanisms of Drug Resistance in Neoplastic Cells is popular PDF and ePub book, written by Paul V. Woolley in 2013-10-22, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Mechanisms of Drug Resistance in Neoplastic Cells can be Read Online from any device for your convenience.
Mechanisms of Drug Resistance in Neoplastic Cells Book PDF Summary
Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.
Detail Book of Mechanisms of Drug Resistance in Neoplastic Cells PDF
- Author : Paul V. Woolley
- Release : 22 October 2013
- Publisher : Elsevier
- ISBN : 9781483220758
- Genre : Medical
- Total Page : 417 pages
- Language : English
- PDF File Size : 12,8 Mb
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