GPCR Signalling Complexes Synthesis Assembly Trafficking and Specificity is popular PDF and ePub book, written by Denis J. Dupré in 2012-11-19, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, GPCR Signalling Complexes Synthesis Assembly Trafficking and Specificity can be Read Online from any device for your convenience.
GPCR Signalling Complexes Synthesis Assembly Trafficking and Specificity Book PDF Summary
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.
Detail Book of GPCR Signalling Complexes Synthesis Assembly Trafficking and Specificity PDF
- Author : Denis J. Dupré
- Release : 19 November 2012
- Publisher : Springer Science & Business Media
- ISBN : 9789400747654
- Genre : Medical
- Total Page : 298 pages
- Language : English
- PDF File Size : 8,7 Mb
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