Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions is popular PDF and ePub book, written by Ang Yan Shan in 2018-09-21, it is a fantastic choice for those who relish reading online the Technology & Engineering genre. Let's immerse ourselves in this engaging Technology & Engineering book by exploring the summary and details provided below. Remember, Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions can be Read Online from any device for your convenience.
Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions Book PDF Summary
This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution. The area of dynamic DNA nanotechnology, or DNA circuits, holds great promise as a highly programmable toolbox that can be used in various applications, including molecular computing and biomolecular detection. However, a key bottleneck is the recurring issue of circuit leakage. The assembly of the localized circuit is dynamically driven by the recognition of biomolecules – a different approach from most methods, which are based on a static DNA origami assembly. The design guidelines for individual reaction modules presented here, which focus on minimizing circuit leakage, are established through NUPACK simulation and tested experimentally – which will be useful for researchers interested in adapting the concepts for other contexts. In the closing section, the design concepts are successfully applied to the biomolecular sensing of a broad range of targets including the single nucleotide mutations, proteins, and cell surface receptors.
Detail Book of Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions PDF
- Author : Ang Yan Shan
- Release : 21 September 2018
- Publisher : Springer
- ISBN : 9789811321887
- Genre : Technology & Engineering
- Total Page : 224 pages
- Language : English
- PDF File Size : 14,7 Mb
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