Endocrine FGFs and Klothos is popular PDF and ePub book, written by Makoto Kuro-o in 2012-03-06, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, Endocrine FGFs and Klothos can be Read Online from any device for your convenience.
Endocrine FGFs and Klothos Book PDF Summary
Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.
Detail Book of Endocrine FGFs and Klothos PDF
- Author : Makoto Kuro-o
- Release : 06 March 2012
- Publisher : Springer Science & Business Media
- ISBN : 9781461408871
- Genre : Science
- Total Page : 250 pages
- Language : English
- PDF File Size : 12,9 Mb
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