Drug Transporters in Drug Disposition Effects and Toxicity is popular PDF and ePub book, written by Xiaodong Liu in 2019-09-30, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Drug Transporters in Drug Disposition Effects and Toxicity can be Read Online from any device for your convenience.
Drug Transporters in Drug Disposition Effects and Toxicity Book PDF Summary
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
Detail Book of Drug Transporters in Drug Disposition Effects and Toxicity PDF
- Author : Xiaodong Liu
- Release : 30 September 2019
- Publisher : Springer Nature
- ISBN : 9789811376474
- Genre : Medical
- Total Page : 580 pages
- Language : English
- PDF File Size : 10,7 Mb
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