Development of New Synthetic Approaches towards the Anthraquinone Xanthone Heterodimeric Structure of Beticolin 0 is popular PDF and ePub book, written by Janina Beck in 2020-09-15, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, Development of New Synthetic Approaches towards the Anthraquinone Xanthone Heterodimeric Structure of Beticolin 0 can be Read Online from any device for your convenience.
Development of New Synthetic Approaches towards the Anthraquinone Xanthone Heterodimeric Structure of Beticolin 0 Book PDF Summary
Mycotoxins are fungal secondary metabolites exhibiting adverse effects on humans, animals as well as crops, resulting in diseases and economic loss. Beticolins are mycotoxins produced by the fungus Cercospora beticola which is responsible for cercosporiosis, commonly known as leaf spot disease, causing heavy damages to crops worldwide. In order to study the mechanism of action of these biologically active compounds, this thesis aimed at the development of synthetic approaches towards the highly complex polycyclic scaffold of beticolins. Beticolins consist of a chlorinated tetrahydroxanthone linked to an anthraquinone subunit via a unique bicyclo[3.2.2]nonane ring system. A facile route towards naphthoquinone derivatives and subsequent Diels-Alder cycloadditions with functionalized dienes afforded a highly functionalized anthraquinone subunit of beticolin 0. For the installation of a tetrahydroxanthone subunit, a synthetic route was elaborated. With the obtained anthraquinone derivatives intramolecular couplings were performed under different conditions, to facilitate the construction of the bicyclo[3.2.2]nonane ring system. The formation of the desired scaffold turned out to be challenging, however a variety of novel bicyclo[3.3.1]systems was obtained, representing interesting scaffolds. During a research stay at the University of Copenhagen, the functionalization of helical beta-peptoids was examined. Peptidomimetics adopting three-dimensional structures with well-defined display of functional groups while being resistant to proteolysis, are of interest for the development of foldamers with a desired function.
Detail Book of Development of New Synthetic Approaches towards the Anthraquinone Xanthone Heterodimeric Structure of Beticolin 0 PDF
- Author : Janina Beck
- Release : 15 September 2020
- Publisher : Logos Verlag Berlin GmbH
- ISBN : 9783832551469
- Genre : Science
- Total Page : 272 pages
- Language : English
- PDF File Size : 21,9 Mb
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