Cytotoxic Payloads for Antibody Drug Conjugates is popular PDF and ePub book, written by David E Thurston in 2019-07-11, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Cytotoxic Payloads for Antibody Drug Conjugates can be Read Online from any device for your convenience.
Cytotoxic Payloads for Antibody Drug Conjugates Book PDF Summary
Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.
Detail Book of Cytotoxic Payloads for Antibody Drug Conjugates PDF
- Author : David E Thurston
- Release : 11 July 2019
- Publisher : Royal Society of Chemistry
- ISBN : 9781788018456
- Genre : Medical
- Total Page : 502 pages
- Language : English
- PDF File Size : 15,8 Mb
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