Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models is popular PDF and ePub book, written by Aslak Tveito in 2016-04-19, it is a fantastic choice for those who relish reading online the Computers genre. Let's immerse ourselves in this engaging Computers book by exploring the summary and details provided below. Remember, Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models can be Read Online from any device for your convenience.
Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models Book PDF Summary
Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.
Detail Book of Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models PDF
- Author : Aslak Tveito
- Release : 19 April 2016
- Publisher : Springer
- ISBN : 9783319300306
- Genre : Computers
- Total Page : 279 pages
- Language : English
- PDF File Size : 10,8 Mb
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