Chloride Channels and Carriers in Nerve Muscle and Glial Cells is popular PDF and ePub book, written by F.J. Alvarez-Leefmans in 2013-06-29, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, Chloride Channels and Carriers in Nerve Muscle and Glial Cells can be Read Online from any device for your convenience.
Chloride Channels and Carriers in Nerve Muscle and Glial Cells Book PDF Summary
This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at thermodynamic equilibrium. These two observations were gener alized and virtually all cells were thought to have a very high P Cl and a ther modynamically passive Cl- transmembrane distribution. These concepts can still be found in some physiology and neuroscience textbooks.
Detail Book of Chloride Channels and Carriers in Nerve Muscle and Glial Cells PDF
- Author : F.J. Alvarez-Leefmans
- Release : 29 June 2013
- Publisher : Springer Science & Business Media
- ISBN : 9781475796858
- Genre : Science
- Total Page : 430 pages
- Language : English
- PDF File Size : 11,5 Mb
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