Chemical Carcinogenesis is popular PDF and ePub book, written by Trevor M. Penning in 2011-03-03, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Chemical Carcinogenesis can be Read Online from any device for your convenience.
Chemical Carcinogenesis Book PDF Summary
This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Detail Book of Chemical Carcinogenesis PDF
- Author : Trevor M. Penning
- Release : 03 March 2011
- Publisher : Springer Science & Business Media
- ISBN : 9781617379956
- Genre : Medical
- Total Page : 447 pages
- Language : English
- PDF File Size : 19,9 Mb
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