Analysis and Control of Cellular Ensembles Exploiting dimensionality reduction in single cell data and models is popular PDF and ePub book, written by Karsten Kuritz in 2020-11-20, it is a fantastic choice for those who relish reading online the Language Arts & Disciplines genre. Let's immerse ourselves in this engaging Language Arts & Disciplines book by exploring the summary and details provided below. Remember, Analysis and Control of Cellular Ensembles Exploiting dimensionality reduction in single cell data and models can be Read Online from any device for your convenience.
Analysis and Control of Cellular Ensembles Exploiting dimensionality reduction in single cell data and models Book PDF Summary
An ensemble system is a collection of nearly identical dynamical systems which admit a certain degree of heterogeneity, and which are subject to the restriction that they may only be manipulated or observed as a whole. This thesis presents analysis and control methods for cellular ensembles by considering reduced 1-dimensional dynamics of biological processes in high-dimensional single-cell data and models. To be more specific, we address the quest for real-time analysis of biological processes within single-cell data by introducing the measure-preserving map of pseudotime into real-time, in short MAPiT. MAPiT enables the reconstruction of temporal and spatial dynamics from single-cell snapshot experiments. In addition, we propose a PDE-constrained learning algorithm which allows for efficient inference of changes in cell cycle progression from time series single-cell snapshot data. The second part of this thesis, is devoted to controlling a heterogeneous cell population, in the sense, that we aim at achieving a desired distribution of cellular oscillators on their periodic orbit. A systems theoretic approach to the ensemble control problem provides novel necessary and sufficient conditions for the control of phase distributions in terms of the Fourier coefficients of the phase response curve. This thesis establishes a connection between the previously separate areas of single cell analysis and ensemble control. Our holistic view opens new perspectives for theoretic concepts in basic research and therapeutic strategies in precision medicine.
Detail Book of Analysis and Control of Cellular Ensembles Exploiting dimensionality reduction in single cell data and models PDF
- Author : Karsten Kuritz
- Release : 20 November 2020
- Publisher : Logos Verlag Berlin GmbH
- ISBN : 9783832552091
- Genre : Language Arts & Disciplines
- Total Page : 150 pages
- Language : English
- PDF File Size : 8,5 Mb
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