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Tuning Autophagy Inducing Activity and Toxicity for Lanthanide Nanocrystals Book PDF Summary

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.

Detail Book of Tuning Autophagy Inducing Activity and Toxicity for Lanthanide Nanocrystals PDF

Tuning Autophagy Inducing Activity and Toxicity for Lanthanide Nanocrystals
  • Author : Yunjiao Zhang
  • Release : 09 January 2022
  • Publisher : Springer Nature
  • ISBN : 9789811681660
  • Genre : Technology & Engineering
  • Total Page : 169 pages
  • Language : English
  • PDF File Size : 19,9 Mb

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