Mechanisms of Genome Protection and Repair is popular PDF and ePub book, written by Dmitry O. Zharkov in 2020-05-07, it is a fantastic choice for those who relish reading online the Medical genre. Let's immerse ourselves in this engaging Medical book by exploring the summary and details provided below. Remember, Mechanisms of Genome Protection and Repair can be Read Online from any device for your convenience.
Mechanisms of Genome Protection and Repair Book PDF Summary
DNA is under constant challenge from environmental and endogenous metabolic assaults. Several layers of defence and repair systems allow cells to maintain stable genomes; in humans, dysfunction of these systems leads to cancer, neurodegeneration, and other pathologies. At the same time, recently it had emerged that targeted and regulated DNA damage and repair is a mechanism underlying several important cellular processes such as epigenetic demethylation and immunoglobulin gene diversification. The present collection of papers is aimed to cover new developments in the area of protective and regulatory mechanisms associated with DNA damage. The mechanisms ruling the recognition of damaged nucleotides against the vast background of normal ones are reviewed. The role of extended non-catalytic domains that are often found in eukaryotic DNA repair proteins in contrast to their downsized, catalytic-only bacterial counterparts is discussed. Among the proposed subjects are the regulatory functions of bulky covalent modifications such as poly(ADP)ribosylation and ubiquitylation in DNA damage response, especially in the context of chromatin remodelling. As opposed to DNA repair, damage tolerance allows cells to replicate with lesions in the genome; the enzymes responsible are also covered. Finally, we present examples of modern multilevel understanding of the cell function and malfunction in the wake of genotoxic assaults such as oxidative stress, abiotic environmental stress, and DNA-damaging plant toxins.
Detail Book of Mechanisms of Genome Protection and Repair PDF
- Author : Dmitry O. Zharkov
- Release : 07 May 2020
- Publisher : Springer Nature
- ISBN : 9783030412838
- Genre : Medical
- Total Page : 230 pages
- Language : English
- PDF File Size : 7,9 Mb
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