Copper Catalyzed Multi Component Reactions is popular PDF and ePub book, written by Yusuke Ohta in 2011-01-20, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, Copper Catalyzed Multi Component Reactions can be Read Online from any device for your convenience.
Copper Catalyzed Multi Component Reactions Book PDF Summary
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.
Detail Book of Copper Catalyzed Multi Component Reactions PDF
- Author : Yusuke Ohta
- Release : 20 January 2011
- Publisher : Springer Science & Business Media
- ISBN : 9783642154737
- Genre : Science
- Total Page : 110 pages
- Language : English
- PDF File Size : 16,6 Mb
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