Artificial Intelligence Platform For Molecular Targeted Therapy A Translational Science Approach is popular PDF and ePub book, written by Ariel Fernandez in 2021-03-12, it is a fantastic choice for those who relish reading online the Science genre. Let's immerse ourselves in this engaging Science book by exploring the summary and details provided below. Remember, Artificial Intelligence Platform For Molecular Targeted Therapy A Translational Science Approach can be Read Online from any device for your convenience.
Artificial Intelligence Platform For Molecular Targeted Therapy A Translational Science Approach Book PDF Summary
In the era of big biomedical data, there are many ways in which artificial intelligence (AI) is likely to broaden the technological base of the pharmaceutical industry. Cheminformatic applications of AI involving the parsing of chemical space are already being implemented to infer compound properties and activity. By contrast, dynamic aspects of the design of drug/target interfaces have received little attention due to the inherent difficulties in dealing with physical phenomena that often do not conform to simplifying views.This book focuses precisely on dynamic drug/target interfaces and argues that the true game change in pharmaceutical discovery will come as AI is enabled to solve core problems in molecular biophysics that are intimately related to rational drug design and drug discovery.Here are a few examples to convey the flavor of our quest: How do we therapeutically impair a dysfunctional protein with unknown structure or regulation but known to be a culprit of disease? In regards to SARS-CoV-2, what is the structural impact of a dominant mutation?, how does the structure change translate into a fitness advantage?, what new therapeutic opportunity arises? How do we extend molecular dynamics simulations to realistic timescales, to capture the rare events associated with drug targeting in vivo? How do we control specificity in drug design to selectively remove side effects? This is the type of problems, directly related to the understanding of drug/target interfaces, that the book squarely addresses by leveraging a comprehensive AI-empowered approach.
Detail Book of Artificial Intelligence Platform For Molecular Targeted Therapy A Translational Science Approach PDF
- Author : Ariel Fernandez
- Release : 12 March 2021
- Publisher : World Scientific
- ISBN : 9789811232329
- Genre : Science
- Total Page : 469 pages
- Language : English
- PDF File Size : 10,7 Mb
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